Sodium Hydroxide → HCID 21973691, 화합물

HRID 11855

반응식

HRID 11855 반응식
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2[NH:11][CH2:12][C:13]2[CH:22]=[CH:21][C:16]([C:17]([O:19]C)=[O:18])=[CH:15][CH:14]=2)[CH:4]=[CH:3][CH:2]=1.[OH-].[Na+]>CO.C1COCC1>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2[NH:11][CH2:12][C:13]2[CH:14]=[CH:15][C:16]([C:17]([OH:19])=[O:18])=[CH:21][CH:22]=2)[CH:4]=[CH:3][CH:2]=1

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 21973698Methyl 4-(8-quinolylaminomethyl)benzoate

생성물 1

HCID 21973691HCID 21973691, 화합물수율 58.8%

시약·촉매·용매 2

HCID 887Methanol용매HCID 8028Tetrahydrofuran용매

실험 절차

The compound obtained in Example 16-1 (1 g) was dissolved in methanol (10 ml), and 1 mol/l aqueous solution of sodium hydroxide (10 ml) was added. The reaction solution was dissolved in THF (10 ml). After the reaction for 7 hours, the reaction solution was concentrated. The obtained residue was dissolved in water and 1 mol/l hydrochloric acid was gradually added while stirring to obtain a precipitate. The precipitate was collected by filtration through glass filter G4 and washed with water to obtain the title compound (560.1 mg) as a pale yellow solid.

후처리

  1. customAfter the reaction for 7 hours
  2. concentrationthe reaction solution was concentrated
  3. dissolutionThe obtained residue was dissolved in water
  4. addition1 mol/l hydrochloric acid was gradually added
  5. customto obtain a precipitate
  6. filtrationThe precipitate was collected by filtration through glass
  7. filtrationfilter G4
  8. washwashed with water

출처 및 근거

ORD 기록
ord-333a087240e745fe8e998f895bad03a7
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07098215B2

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