Acetic Anhydride → N-(3-Iodo-2-methylphenyl)acetamide
반응식
[I:1][C:2]1[C:3]([CH3:9])=[C:4]([CH:6]=[CH:7][CH:8]=1)[NH2:5].[C:10](OC(=O)C)(=[O:12])[CH3:11]>C(O)(=O)C>[C:10]([NH:5][C:4]1[CH:6]=[CH:7][CH:8]=[C:2]([I:1])[C:3]=1[CH3:9])(=[O:12])[CH3:11]참가 물질
4
실험 절차
Charge a 5 L, 3 neck flask equipped with a mantle, stirrer, condenser, with 708 grams (5M) 3-Iodo-2-Methyl Aniline, followed by 700 ml glacial acetic acid. Add in a stream of 520 grams (5.1M) acetic anhydride and allow the solution to come to a gentle reflux for an hour. The solution is allowed to cool and poured in a stream in a large container of 8 L ice water. The product will crystallize immediately and is filtered and squeezed under vacuum and air-dried. Yield was 900 grams (Theoretical yield=918 g).
후처리
- additionCharge a 5 L, 3 neck flask
- customequipped with a mantle, stirrer, condenser
- temperaturea gentle reflux for an hour
- temperatureto cool
- customThe product will crystallize immediately
- filtrationis filtered
- customair-dried
출처 및 근거
- ORD 기록
- ord-16cceccfd18c4d05bcbde8bb252c462d
- 출처 데이터셋
- uspto-grants-2014_03
- 특허 번호
- US08673269B2
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