Sodium borohydride → Methyl 4'-(hydroxymethyl)-[1,1'-biphenyl]-2-carboxylate

HRID 1186029

반응식

HRID 1186029 반응식
[BH4-].[Na+].[CH:3]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[C:12]([C:17]([O:19][CH3:20])=[O:18])=[CH:13][CH:14]=[CH:15][CH:16]=2)=[CH:7][CH:6]=1)=[O:4]>CO>[OH:4][CH2:3][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[C:12]([C:17]([O:19][CH3:20])=[O:18])=[CH:13][CH:14]=[CH:15][CH:16]=2)=[CH:7][CH:6]=1

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 4325150Methyl 2-(4-formylphenyl)benzoate

생성물 1

HCID 15380881Methyl 4'-(hydroxymethyl)-[1,1'-biphenyl]-2-carboxylate수율 99.2%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Sodium borohydride (111 mg) was added to the compound (400 mg) prepared in Example 4 in methanol solution (10 mL) and stirred for 1 hour at room temperature. The reaction mixture was concentrated and extracted with 1 mol/L hydrochloric acid and ethyl acetate. The organic layer was washed with saturated sodium and dried by anhydrous sodium sulfate, and then concentrated to obtain the titled compound (400 mg) having the following physical data.

후처리

  1. concentrationThe reaction mixture was concentrated
  2. extractionextracted with 1 mol/L hydrochloric acid and ethyl acetate
  3. washThe organic layer was washed with saturated sodium
  4. dry with materialdried by anhydrous sodium sulfate
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-ab82958328ea41619d1ccd1c77d93663
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08673889B2

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