Sodium Hydroxide → 2-Amino-5-chloro-3-methoxybenzoic acid

HRID 1186093

반응식

HRID 1186093 반응식
[NH2:1][C:2]1[C:11]([O:12][CH3:13])=[CH:10][C:9]([Cl:14])=[CH:8][C:3]=1[C:4]([O:6]C)=[O:5].[OH-].[Na+]>O1CCCC1>[NH2:1][C:2]1[C:11]([O:12][CH3:13])=[CH:10][C:9]([Cl:14])=[CH:8][C:3]=1[C:4]([OH:6])=[O:5]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 58566618Methyl 2-amino-5-chloro-3-methoxybenzoate

생성물 1

HCID 545958742-Amino-5-chloro-3-methoxybenzoic acid

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Methyl 2-amino-5-chloro-3-methoxybenzoate (770 mg, 3.57 mmol) was suspended in tetrahydrofuran (20 mL), 2M sodium hydroxide (5 mL) was added and the mixture was stirred at ambient temperature for 20 hours. The solution was concentrated in vacuo, then partitioned between ethyl acetate and 1M hydrochloric acid. The organic layer was washed with water, then brine, dried with sodium sulfate, decanted and concentrated in vacuo to yield 2-amino-5-chloro-3-methoxybenzoic acid.

후처리

  1. concentrationThe solution was concentrated in vacuo
  2. custompartitioned between ethyl acetate and 1M hydrochloric acid
  3. washThe organic layer was washed with water
  4. dry with materialbrine, dried with sodium sulfate
  5. customdecanted
  6. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-1edf70473893420eb539e1c3e358e451
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08673897B2

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