Potassium Carbonate → 2,2,2-Trifluoro-1-(2-morpholinothiazol-5-yl)ethanol

HRID 1186376

반응식

HRID 1186376 반응식
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[S:8][C:9]([CH:12]=[O:13])=[CH:10][N:11]=2)[CH2:3][CH2:2]1.C(=O)([O-])[O-].[K+].[K+].[F:20][C:21]([Si](C)(C)C)([F:23])[F:22]>CN(C)C=O>[F:20][C:21]([F:23])([F:22])[CH:12]([C:9]1[S:8][C:7]([N:4]2[CH2:5][CH2:6][O:1][CH2:2][CH2:3]2)=[N:11][CH:10]=1)[OH:13]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 552549(Trifluoromethyl)trimethylsilaneHCID 14797702-(Morpholin-4-yl)-1,3-thiazole-5-carbaldehyde

생성물 1

HCID 674017402,2,2-Trifluoro-1-(2-morpholinothiazol-5-yl)ethanol수율 65.1%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

According to Reference Example 8-2, by use of 2-morpholinothiazole-5-carbaldehyde (177 mg, 0.893 mmol) dissolved in N,N-dimethylformamide (5.3 mL), potassium carbonate (25 mg, 0.18 mmol) and (trifluoromethyl)trimethylsilane (0.198 mL, 1.34 mmol), the mixture was stirred and reacted at room temperature for 2.3 hours. Then, purification by preparative thin-layer chromatography (chloroform/methanol=15/1) was performed to give 2,2,2-trifluoro-1-(2-morpholinothiazol-5-yl)ethanol (Compound DY) (156 mg, yield: 65%).

후처리

  1. customreacted at room temperature for 2.3 hours
  2. customThen, purification by preparative thin-layer chromatography (chloroform/methanol=15/1)

출처 및 근거

ORD 기록
ord-c2161b8b710a4619b109609db1ebd983
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08673908B2

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