Acetic Acid → HCID 58316762, 화합물

HRID 1187281노트

반응식

HRID 1187281 반응식
[Cl:1][C:2]1[C:3]([NH2:11])=[C:4]2[CH:10]=[CH:9][NH:8][C:5]2=[N:6][CH:7]=1.C(O)(=O)C.C([BH3-])#N.[Na+].[CH:20]1([CH:23]=O)[CH2:22][CH2:21]1>C(O)C>[Cl:1][C:2]1[C:3]([NH:11][CH2:23][CH:20]2[CH2:22][CH2:21]2)=[C:4]2[CH:10]=[CH:9][NH:8][C:5]2=[N:6][CH:7]=1

참가 물질

6

반응물 4

HCID 176Acetic AcidHCID 123114CyclopropanecarboxaldehydeHCID 5003444Sodium cyanoborohydrideHCID 260764515-Chloro-1H-pyrrolo[2,3-b]pyridin-4-amine

생성물 1

HCID 58316762HCID 58316762, 화합물수율 69%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

In a round bottom flask, 5-chloro-1H-pyrrolo[2,3-b]pyridin-4-ylamine (22, 0.21 g, 1.25 mmol) is combined with 3.5 mL of ethanol, acetic acid (0.38 g, 6.25 mmol), silica bound sodium cyanoborohydride (1.1 g, 1.02 mmol), and cyclopropanecarbaldehyde (23, 0.26 g, 4 mmol). The reaction mixture was stirred over night at room temperature, heated up to 145° C. until the reaction was complete, filtered, concentrated, and purified by flash chromatography to provide compound as a solid (24, 0.191 g; yield=69%).

후처리

  1. temperatureheated up to 145° C. until the reaction
  2. filtrationfiltered
  3. concentrationconcentrated
  4. custompurified by flash chromatography

출처 및 근거

ORD 기록
ord-2388f06458044909afcd41a050baa81d
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08673928B2

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