2-Aminothiazole → HCID 59408784, 화합물

HRID 1188127노트

반응식

HRID 1188127 반응식
[CH3:1][N:2]([CH:10]1[CH2:15][CH2:14][CH2:13][CH2:12][O:11]1)[C:3]1[S:4][C:5]([CH:8]=O)=[CH:6][N:7]=1.[NH2:16][C:17]1[S:18][CH:19]=[CH:20][N:21]=1.[BH4-].[Na+]>C1(C)C=CC=CC=1.CCO>[CH3:1][N:2]([CH:10]1[CH2:15][CH2:14][CH2:13][CH2:12][O:11]1)[C:3]1[S:4][C:5]([CH2:8][NH:16][C:17]2[S:18][CH:19]=[CH:20][N:21]=2)=[CH:6][N:7]=1

참가 물질

6

반응물 3

HCID 21552-AminothiazoleHCID 4311764Sodium borohydrideHCID 59408736HCID 59408736, 화합물

생성물 1

HCID 59408784HCID 59408784, 화합물수율 17%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 1140Toluene용매

실험 절차

A solution of 2-(methyl(tetrahydro-2H-pyran-2-yl)amino)thiazole-5-carbaldehyde (250 mg, 1.10 mmol) and 2-aminothiazole (110 mg, 1.10 mmol) in toluene (11 mL) and molecular sieves 3 Å were stirred at reflux overnight. The strongly yellow solution of the corresponding imine was then poured over NaBH4 (212 mg, 5.61 mmol) in hot EtOH (80 mL). The colorless solution was filtered, concentrated and purified by column chromatography yielding N-methyl-N-(tetrahydro-2H-pyran-2-yl)-5-((thiazol-2-ylamino)methyl)thiazol-2-amine (50 mg, 17%) as a solid.

후처리

  1. temperatureat reflux overnight
  2. filtrationThe colorless solution was filtered
  3. concentrationconcentrated
  4. custompurified by column chromatography

출처 및 근거

ORD 기록
ord-50a0e5ad13404172a0fc839a301c4695
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08673940B2

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