HCID 59408784, 화합물 → HCID 25001115, 화합물

HRID 1188128노트

반응식

HRID 1188128 반응식
[CH3:1][N:2](C1CCCCO1)[C:3]1[S:4][C:5]([CH2:8][NH:9][C:10]2[S:11][CH:12]=[CH:13][N:14]=2)=[CH:6][N:7]=1>C(O)(C(F)(F)F)=O.C(Cl)(Cl)Cl>[CH3:1][NH:2][C:3]1[S:4][C:5]([CH2:8][NH:9][C:10]2[S:11][CH:12]=[CH:13][N:14]=2)=[CH:6][N:7]=1

참가 물질

4

반응물 1

HCID 59408784HCID 59408784, 화합물

생성물 1

HCID 25001115HCID 25001115, 화합물수율 77.3%

시약·촉매·용매 2

HCID 6212Chloroform용매HCID 6422Trifluoroacetic acid용매

실험 절차

A solution of N-methyl-N-(tetrahydro-2H-pyran-2-yl)-5-((thiazol-2-ylamino)methyl) thiazol-2-amine (50 mg, 0.16 mmol) in 10% TFA in CHCl3 (5 mL) was stirred at RT overnight. After evaporating the solvent, the residue was dissolved in MeOH, neutralized with Na2CO3 and extracted with CHCl3. The organic phase was dried, concentrated and purified by column chromatography yielding N-methyl-5-((thiazol-2-ylamino)methyl)thiazol-2-amine (28 mg, 77%) as a solid.

후처리

  1. customAfter evaporating the solvent
  2. dissolutionthe residue was dissolved in MeOH
  3. extractionextracted with CHCl3
  4. customThe organic phase was dried
  5. concentrationconcentrated
  6. custompurified by column chromatography

출처 및 근거

ORD 기록
ord-a27ef617d8964f4891dd1b840f4bca0b
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08673940B2

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