Iodoethane → 3-(3,5-Difluorophenyl)-1-ethyl-3-methoxypyrrolidine

HRID 1188163노트

반응식

HRID 1188163 반응식
[F:1][C:2]1[CH:3]=[C:4]([C:9]2([O:14][CH3:15])[CH2:13][CH2:12][NH:11][CH2:10]2)[CH:5]=[C:6]([F:8])[CH:7]=1.[CH2:16](N(CC)CC)[CH3:17].ICC>O1CCCC1.CO>[F:1][C:2]1[CH:3]=[C:4]([C:9]2([O:14][CH3:15])[CH2:13][CH2:12][N:11]([CH2:16][CH3:17])[CH2:10]2)[CH:5]=[C:6]([F:8])[CH:7]=1

참가 물질

6

반응물 3

HCID 6340IodoethaneHCID 8471TriethylamineHCID 199358743-(3,5-Difluorophenyl)-3-methoxypyrrolidine

생성물 1

HCID 462192253-(3,5-Difluorophenyl)-1-ethyl-3-methoxypyrrolidine

시약·촉매·용매 2

HCID 887Methanol용매HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of (+)-3-(3,5-difluorophenyl)-3-methoxypyrrolidine (0.01 g, 0.047 mmol) and triethylamine (13.1 μL, 0.0938 mmol) in tetrahydrofuran (3 ml), was added iodoethane (5.6 μL, 0.070 mmol). The resulting mixture was stirred at ambient temperature for 24 h and then diluted with methanol and analyzed by GCMS and LCMS. Analysis show 64% conversion. MS m/z (relative intensity, 70 eV) 241 (M+, 10), 226 (86), 211 (33), 141 (49), 71 (bp).

출처 및 근거

ORD 기록
ord-536c84e5ce7c4ec596d4f684cfe77cdb
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08673962B2

반응 노트

불러오는 중…