홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Trifluoroacetic acid → cyclopentyl-3-((3-(4-(methylsulfonamido)phenyl)-4-oxo-4H-chromen-7-yl)ethynyl)azetidine-1-carboxylate

HRID 1188264
노트
인쇄 미리보기

반응식

HRID 1188264 반응식
[NH:1]1[CH2:4][CH:3]([C:5]#[C:6][C:7]2[CH:16]=[C:15]3[C:10]([C:11](=[O:28])[C:12]([C:17]4[CH:22]=[CH:21][C:20]([NH:23][S:24]([CH3:27])(=[O:26])=[O:25])=[CH:19][CH:18]=4)=[CH:13][O:14]3)=[CH:9][CH:8]=2)[CH2:2]1.FC(F)(F)C(O)=O.[C:36](=O)([O:43]N1C(=O)CCC1=O)[O:37][CH:38]1[CH2:42][CH2:41][CH2:40][CH2:39]1.C(N(C(C)C)CC)(C)C>ClCCl>[CH:38]1([O:37][C:36]([N:1]2[CH2:4][CH:3]([C:5]#[C:6][C:7]3[CH:16]=[C:15]4[C:10]([C:11](=[O:28])[C:12]([C:17]5[CH:22]=[CH:21][C:20]([NH:23][S:24]([CH3:27])(=[O:26])=[O:25])=[CH:19][CH:18]=5)=[CH:13][O:14]4)=[CH:9][CH:8]=3)[CH2:2]2)=[O:43])[CH2:42][CH2:41][CH2:40][CH2:39]1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 6422Trifluoroacetic acidHCID 81531DiisopropylethylamineHCID 15927743N-(Cyclopentyloxycarbonyloxy)succinimideHCID 71506445N-(4-(7-(azetidin-3-ylethynyl)-4-oxo-4H-chromen-3-yl)phenyl)methanesulfonamide

생성물 1

HCID 71506446cyclopentyl-3-((3-(4-(methylsulfonamido)phenyl)-4-oxo-4H-chromen-7-yl)ethynyl)azetidine-1-carboxylate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a mixture of N-(4-(7-(azetidin-3-ylethynyl)-4-oxo-4H-chromen-3-yl)phenyl)methanesulfonamide.trifluoroacetic acid salt (55 mgs, 0.140 mmol) in dichloromethane (3 mL) was added cyclopentyl 2,5-dioxopyrrolidin-1-yl carbonate (95 mgs, 0.42 mmol) and diisopropylethylamine (0.2 mL, 1.4 mmol), and the mixture was stirred at room temperature for 16 hours. The resulting mixture was concentrated under reduced pressure, and chromatographed (SiO2, 25% ethyl acetate/dichloromethane) to provide cyclopentyl-3-((3-(4-(methylsulfonamido)phenyl)-4-oxo-4H-chromen-7-yl)ethynyl)azetidine-1-carboxylate:

후처리

  1. concentrationThe resulting mixture was concentrated under reduced pressure
  2. customchromatographed (SiO2, 25% ethyl acetate/dichloromethane)

출처 및 근거

ORD 기록
ord-227737d604f043dea950a514f9124930
출처 데이터셋
uspto-grants-2014_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08673966B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트