Piperazine → 2-Methyl-1-(4-methylsulfanylphenyl)-2-piperazin-1-yl-propan-1-one

HRID 1188296

반응식

HRID 1188296 반응식
CO[C:3]1([C:8]2[CH:13]=[CH:12][C:11]([S:14][CH3:15])=[CH:10][CH:9]=2)[C:5]([CH3:7])([CH3:6])[O:4]1.[NH:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1>ClCCl>[CH3:6][C:5]([N:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1)([CH3:7])[C:3]([C:8]1[CH:13]=[CH:12][C:11]([S:14][CH3:15])=[CH:10][CH:9]=1)=[O:4]

참가 물질

4

반응물 2

HCID 4837PiperazineHCID 201925252-Methoxy-3,3-dimethyl-2-(4-methylsulfanylphenyl)oxirane

생성물 1

HCID 233257252-Methyl-1-(4-methylsulfanylphenyl)-2-piperazin-1-yl-propan-1-one

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
130 °C

실험 절차

Further, in a 500 mL four-neck flask provided with a stirrer, a condenser, and a thermocouple, the compound (c) and 31 g of piperazine were added, followed by stirring at 130° C. for 6 hours. After cooling, 80 mL of dichloromethane was added, and an organic layer was washed three times with 70 mL of water. The organic layer was dried with anhydrous sodium sulfate and concentrated to produce 60.7 g of 2-methyl-1-(4-methylsulfanylphenyl)-2-piperazin-1-yl-propan-1-one (12).

후처리

  1. customFurther, in a 500 mL four-neck flask provided with a stirrer, a condenser
  2. temperatureAfter cooling
  3. washan organic layer was washed three times with 70 mL of water
  4. dry with materialThe organic layer was dried with anhydrous sodium sulfate
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-924c4bc3a53c456787de4b2d41573fe2
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08674089B2

연결된 노트

불러오는 중…