참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Piperazine | HCID 4837 | — |
| 반응물 | 2-Methoxy-3,3-dimethyl-2-(4-methylsulfanylphenyl)oxirane | HCID 20192525 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2-Methyl-1-(4-methylsulfanylphenyl)-2-piperazin-1-yl-propan-1-one | HCID 23325725 | — |
반응 단계
Further, in a 500 mL four-neck flask provided with a stirrer, a condenser, and a thermocouple, the compound (c) and 31 g of piperazine were added, followed by stirring at 130° C. for 6 hours. After cooling, 80 mL of dichloromethane was added, and an organic layer was washed three times with 70 mL of water. The organic layer was dried with anhydrous sodium sulfate and concentrated to produce 60.7 g of 2-methyl-1-(4-methylsulfanylphenyl)-2-piperazin-1-yl-propan-1-one (12).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08674089B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_03 |
|---|
| ORD ID | ord-924c4bc3a53c456787de4b2d41573fe2 |
|---|
| 출처 메모 | uspto-grants-2014_03 |
|---|
