2-Amino-4-chlorophenol → HCID 86086750, 화합물
반응식
[CH3:1][O:2][C:3](=[NH:8])[CH2:4][CH2:5][C:6]#[CH:7].N[C:10]1[CH:15]=[C:14]([Cl:16])[CH:13]=[CH:12]C=1O>ClC(Cl)C>[CH2:4]([C:3]1[O:2][C:1]2[CH:10]=[CH:15][C:14]([Cl:16])=[CH:13][C:12]=2[N:8]=1)[CH2:5][C:6]#[CH:7]참가 물질
4
실험 절차
A mixture of pent-4-ynimidic acid methyl ester (142 mg, 1.28 mmol) and 2-amino-4-chlorophenol (227 mg, 1.53 mmol) in dichloroethane (10 mL) was stirred for 2 days under reflux. The solvent was evaporated, the residue was partly dissolved in MeOH and filtered. The filtrate was concentrated, and the resulting crude residue was purified by flash chromatography (cyclohexane/AcOEt 9:1) to yield 18 mg (87 μmol, 7%) of 2-(but-3-ynyl)-5-chlorobenzo[d]oxazole.
후처리
- temperatureunder reflux
- customThe solvent was evaporated
- dissolutionthe residue was partly dissolved in MeOH
- filtrationfiltered
- concentrationThe filtrate was concentrated
- customthe resulting crude residue was purified by flash chromatography (cyclohexane/AcOEt 9:1)
출처 및 근거
- ORD 기록
- ord-275d77ccbccc49b99777bc75c38a400b
- 출처 데이터셋
- uspto-grants-2014_03
- 특허 번호
- US08674106B2
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