Acetic Acid → 3-Amino-2,4-dichlorobenzoic acid

HRID 1189606노트

반응식

HRID 1189606 반응식
C([NH:4][C:5]1[C:6]([Cl:15])=[C:7]([CH:11]=[CH:12][C:13]=1[Cl:14])[C:8]([OH:10])=[O:9])(=O)C.C(O)(=O)C>Cl>[NH2:4][C:5]1[C:6]([Cl:15])=[C:7]([CH:11]=[CH:12][C:13]=1[Cl:14])[C:8]([OH:10])=[O:9]

참가 물질

4

반응물 2

HCID 176Acetic AcidHCID 198331103-Acetamido-2,4-dichlorobenzoic acid

생성물 1

HCID 152782343-Amino-2,4-dichlorobenzoic acid

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

3-Acetylamino-2,4-dichloro-benzoic acid (21.0 g, 84.6 mmol) is stirred in 6 M aq HCl-solution (120 mL) and acetic acid (250 mL) at reflux for 24 h. The reaction mixture is cooled, concentrated, diluted with water and concentrated again. The residue is diluted with water, stirred under cooling and filtered. The filtercake is washed and dried to give the sub-title compound.

후처리

  1. temperatureThe reaction mixture is cooled
  2. concentrationconcentrated
  3. additiondiluted with water
  4. concentrationconcentrated again
  5. additionThe residue is diluted with water
  6. temperatureunder cooling
  7. filtrationfiltered
  8. washThe filtercake is washed
  9. customdried

출처 및 근거

ORD 기록
ord-0fb18df8ad46480fb98862853207123a
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08674113B2

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