Hydrochloric Acid → 2-(4-Fluoro-piperidinyl)-4-amino-5-nitro-benzoic acid

HRID 1189637노트

반응식

HRID 1189637 반응식
[F:1][CH:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.Cl.F[C:10]1[CH:18]=[C:17]([NH2:19])[C:16]([N+:20]([O-:22])=[O:21])=[CH:15][C:11]=1[C:12]([OH:14])=[O:13]>CN(C=O)C>[F:1][CH:2]1[CH2:7][CH2:6][N:5]([C:10]2[CH:18]=[C:17]([NH2:19])[C:16]([N+:20]([O-:22])=[O:21])=[CH:15][C:11]=2[C:12]([OH:14])=[O:13])[CH2:4][CH2:3]1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 27591594-FluoropiperidineHCID 597853374-Amino-2-fluoro-5-nitrobenzoic acid

생성물 1

HCID 679575752-(4-Fluoro-piperidinyl)-4-amino-5-nitro-benzoic acid

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
50 °C

실험 절차

A mixture of 4-fluoropiperidine×HCl (691 mg, 4.9 mmol), TEA (2.2 ml, 16 mmol), 2-fluoro-4-amino-5-nitro-benzoic acid (900 mg, 4.5 mmol) and DMF (15 mL) is stirred for 4.5 h at 50° C. Then the mixture is concentrated, diluted with water and the precipitate is filtered and dried.

후처리

  1. concentrationThen the mixture is concentrated
  2. additiondiluted with water
  3. filtrationthe precipitate is filtered
  4. customdried

출처 및 근거

ORD 기록
ord-35ee84f79cc6462dbbf0a5b683efb792
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08674113B2

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