Hydrochloric Acid → 2-Chloro-4-(methylamino)-5-nitrobenzoic acid

HRID 1189642노트

반응식

HRID 1189642 반응식
[CH3:1][NH2:2].[Cl:3][C:4]1[CH:12]=[C:11](F)[C:10]([N+:14]([O-:16])=[O:15])=[CH:9][C:5]=1[C:6]([OH:8])=[O:7].Cl>O>[Cl:3][C:4]1[CH:12]=[C:11]([NH:2][CH3:1])[C:10]([N+:14]([O-:16])=[O:15])=[CH:9][C:5]=1[C:6]([OH:8])=[O:7]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 6329Methylamine2회HCID 72108282-Chloro-4-fluoro-5-nitrobenzoic Acid

생성물 1

HCID 679575072-Chloro-4-(methylamino)-5-nitrobenzoic acid

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

Methylamine (40% aq solution, 8.25 mL) is added to an ice-cooled mixture of 2-chloro-4-fluoro-5-nitro-benzoic acid (7.00 g, 31 mmol) and 70 mL water. After 2 h additional 0.5 mL methylamine solution is added and it is stirred for additional 3 h. Then 200 mL of water and 47 mL 1N aq HCl are added and the resulting precipitate is filtered off, washed with water and dried.

후처리

  1. temperaturecooled
  2. filtrationthe resulting precipitate is filtered off
  3. washwashed with water
  4. customdried

출처 및 근거

ORD 기록
ord-8d60785c8f6441819d6d5a234b3e4897
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08674113B2

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