HCID 67957189, 화합물 → Methyl-2-[4-trifluoromethyl-piperidinyl]-4-methylamino-5-amino-benzoate

HRID 1189687노트

반응식

HRID 1189687 반응식
[CH3:1][O:2][C:3](=[O:25])[C:4]1[CH:9]=[C:8]([N+:10]([O-])=O)[C:7]([NH:13][CH3:14])=[CH:6][C:5]=1[N:15]1[CH2:20][CH2:19][CH:18]([C:21]([F:24])([F:23])[F:22])[CH2:17][CH2:16]1>[Ni].CO>[CH3:1][O:2][C:3](=[O:25])[C:4]1[CH:9]=[C:8]([NH2:10])[C:7]([NH:13][CH3:14])=[CH:6][C:5]=1[N:15]1[CH2:16][CH2:17][CH:18]([C:21]([F:22])([F:24])[F:23])[CH2:19][CH2:20]1

참가 물질

4

반응물 1

HCID 67957189HCID 67957189, 화합물

생성물 1

HCID 67957313Methyl-2-[4-trifluoromethyl-piperidinyl]-4-methylamino-5-amino-benzoate

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매

실험 절차

A mixture of methyl-2-[4-trifluoromethyl-piperidinyl]-4-methylamino-5-nitro-benzoate (1.80 g, 4.19 mmol), Ra—Ni (200 mg) and MeOH (100 mL) is stirred for 5 h under 3 bar H2-atmosphere. The mixture is filtered, and the filtrate is concentrated.

후처리

  1. filtrationThe mixture is filtered
  2. concentrationthe filtrate is concentrated

출처 및 근거

ORD 기록
ord-8bb9092817144b45a52ccc97a863ed9e
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08674113B2

반응 노트

불러오는 중…