Ethanamine, 2,2,2-trifluoro- → HCID 58495575, 화합물

HRID 1191074노트

반응식

HRID 1191074 반응식
[F:1][C:2]([F:6])([F:5])[CH2:3][NH2:4].[C:7]([N:15]=[C:16]=[S:17])(=[O:14])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>C(Cl)(Cl)Cl>[C:7]([NH:15][C:16]([NH:4][CH2:3][C:2]([F:6])([F:5])[F:1])=[S:17])(=[O:14])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

참가 물질

4

반응물 2

HCID 9773Ethanamine, 2,2,2-trifluoro-HCID 68284Benzoyl isothiocyanate

생성물 1

HCID 58495575HCID 58495575, 화합물수율 95.3%

시약·촉매·용매 1

HCID 6212Chloroform용매2회

실험 절차

Dissolve trifluoroethylamine (2.2 g, 22 mmol) in chloroform (20 mL) and add the solution to a mixture of benzoyl isothiocyanate (3.5 g, 22 mmol) in chloroform (20 mL) at room temperature. Stir the mixture in a sealed flask for 16 h at room temperature. Concentrate the mixture in vacuo to obtain the desired intermediate as a solid (5.5 g, 95%). MS (ES+) m/z: 263 (M+H)+.

후처리

  1. additionadd the solution
  2. concentrationConcentrate the mixture in vacuo

출처 및 근거

ORD 기록
ord-3e9c2283b2e24c9095854aa0f24a1371
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08680091B2

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