m-Chloroperbenzoic acid → Furo[3,2-b]pyridine 4-oxide
반응식
[O:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.C1C=C(Cl)C=C(C(OO)=[O:18])C=1>C(Cl)(Cl)Cl>[O:1]1[C:9]2[C:4](=[N+:5]([O-:18])[CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1참가 물질
4
실험 절차
To a solution of Furo[3,2-b]pyridine (1.5 g, 13.0 mmol) in CHCl3 (30 mL) was added MCPBA (2.9 g, 17.0 mmol). The mixture was stirred at room temperature for 16 hours. Then the mixture was filtered through a alumina (140 g, basic) and washed with ethyl acetate/hexane (1:1) and DCM/MeOH (20:1) to give Furo[3,2-b]pyridine 4-oxide (1.49 g, 88%). 1H NMR (CDCl3, 400 MHz) δ 8.25 (m, 1H), 7.81 (m, 1H), 7.51 (m, 1H), 7.23 (m, 1H).
후처리
- filtrationThen the mixture was filtered through a alumina (140 g, basic)
- washwashed with ethyl acetate/hexane (1:1) and DCM/MeOH (20:1)
출처 및 근거
- ORD 기록
- ord-9f3a2bcc15604a0da768bf3018928a71
- 출처 데이터셋
- uspto-grants-2014_03
- 특허 번호
- US08680114B2
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