Hydroxyamine hydrochloride → HCID 6400952, 화합물

HRID 1192820노트

반응식

HRID 1192820 반응식
Cl.[NH2:2][OH:3].[CH3:4][NH:5][C:6](=[O:15])[C:7](=O)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>N1C=CC=CC=1>[OH:3][N:2]=[C:7]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:6]([NH:5][CH3:4])=[O:15]

참가 물질

4

반응물 2

HCID 443297Hydroxyamine hydrochlorideHCID 10877451N-methyl-2-oxo-2-phenylacetamide

생성물 1

HCID 6400952HCID 6400952, 화합물

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

Hydroxylamine hydrochloride (5.96 g, 2.5 eq.) was added to a solution of N-methyl-2-oxo-2-phenylacetamide (5.6 g, 34.3 mmol) in pyridine (25 ml). After stirring for 10 h at room temperature, the excess pyridine was removed in vacuo and the residue was taken up in 250 ml of dichloromethane. The organic phase was washed with 200 ml of water and then again with aqueous hydrochloric acid (0.1 M, 250 ml). The precipitated solid was filtered off, giving 2-(hydroxyimino)-N-methyl-2-phenylacetamide as a yellow solid (2.31 g, pure Z isomer). The filtrate was concentrated by evaporation in vacuo. This gave 4.50 g of 2-(hydroxyimino)-N-methyl-2-phenylacetamide (Z/E=mixture of isomers) as a yellow solid.

후처리

  1. customthe excess pyridine was removed in vacuo
  2. washThe organic phase was washed with 200 ml of water
  3. filtrationThe precipitated solid was filtered off

출처 및 근거

ORD 기록
ord-3a6b693839be4a0aaf45d529f4caa07e
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08680283B2

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