Sodium Hydroxide → 4-(2-Fluoro-4-nitrophenyl)butanoic acid

HRID 1192866노트

반응식

HRID 1192866 반응식
[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:4][C:3]=1[CH2:11][CH2:12][CH2:13][C:14]([O:16]C)=[O:15].[OH-].[Na+]>CO.O>[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:4][C:3]=1[CH2:11][CH2:12][CH2:13][C:14]([OH:16])=[O:15]

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 57672633Methyl 4-(2-fluoro-4-nitrophenyl)butanoate

생성물 1

HCID 576726244-(2-Fluoro-4-nitrophenyl)butanoic acid수율 98%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

반응 조건

온도
21 °C

실험 절차

To a solution of Methyl 4-(2-fluoro-4-nitrophenyl)butanoate (84) (43 mg, 0.18 mmol) in methanol (1 mL) and water (3 mL) was added sodium hydroxide (0.18 g, 4.50 mmol). The reaction mixture was stirred at 21° C. overnight. The reaction mixture was quenched with 1 N HCl solution and extracted with ethyl acetate (2×30 mL). The organic layer was dried over MgSO4, concentrated to give 4-(2-Fluoro-4-nitrophenyl)butanoic acid (82) (40 mg, 98%) and the residue was used without further purification.

후처리

  1. customThe reaction mixture was quenched with 1 N HCl solution
  2. extractionextracted with ethyl acetate (2×30 mL)
  3. dry with materialThe organic layer was dried over MgSO4
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-c71ece2c8d0646d6ac844b492fcb7d6f
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08680291B2

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