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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Potassium Carbonate → (1R,6S)-8-(3-Methylpyrazin-2-yl)-3,8-diazabicyclo[4.2.0]octane

HRID 1193083
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인쇄 미리보기

반응식

HRID 1193083 반응식
FC(F)(F)C1[CH:8]=[CH:7][N:6]=[C:5]([N:9]2[C@@H:16]3[C@@H:11]([CH2:12][CH2:13][NH:14][CH2:15]3)[CH2:10]2)N=1.ClC1N=C(C(F)(F)F)[CH:23]=[CH:22][N:21]=1.C([O-])([O-])=O.[K+].[K+].CCN(C(C)C)C(C)C>C(#N)C.CN(C=O)C>[CH3:23][C:22]1[C:5]([N:9]2[C@@H:16]3[C@@H:11]([CH2:12][CH2:13][NH:14][CH2:15]3)[CH2:10]2)=[N:6][CH:7]=[CH:8][N:21]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 4

HCID 11430Potassium CarbonateHCID 81531DiisopropylethylamineHCID 27739122-Chloro-4-(trifluoromethyl)pyrimidineHCID 67116508HCID 67116508, 화합물

생성물 1

HCID 67116913(1R,6S)-8-(3-Methylpyrazin-2-yl)-3,8-diazabicyclo[4.2.0]octane

시약·촉매·용매 2

HCID 6228Dimethylformamide용매

실험 절차

The title compound was prepared in a manner analogous to Intermediate 27, substituting 2-chloro-3-methylpyrazine for 2-chloro-4-(trifluoromethyl)pyrimidine. In addition, DMF and K2CO3 at 95° C. was used in place of DIPEA and ACN.

후처리

  1. customat 95° C.

출처 및 근거

ORD 기록
ord-288c73417fe44ba1a28da2a9cb500103
출처 데이터셋
uspto-grants-2014_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08680275B2

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이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트
HCID 6342
Acetonitrile
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