Methanol → 3-Methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid
반응식
[CH3:1][C:2]1[C:3]([N:10]2[N:14]=[CH:13][CH:12]=[N:11]2)=[C:4]([CH:7]=[CH:8][CH:9]=1)[C:5]#N.[OH-:15].[Na+].C[OH:18]>O>[CH3:1][C:2]1[C:3]([N:10]2[N:14]=[CH:13][CH:12]=[N:11]2)=[C:4]([CH:7]=[CH:8][CH:9]=1)[C:5]([OH:18])=[O:15]참가 물질
5
반응 조건
- 온도
- 90 °C
실험 절차
To a solution of 3-methyl-2-(2H-1,2,3-triazol-2-yl)benzonitrile (1.4 g, 7.82 mmol) in MeOH (15 mL) was added a 4N aqueous solution of NaOH (10 mL). The resulting mixture was heated to 90° C. After 15 h the reaction mixture was cooled to ambient temperature then diluted with water (50 mL). The aqueous layer was acidified to pH2 and extracted with EtOAc (50 mL) three times. The organic layers were combined, dried over Na2SO4, filtered and concentrated.
후처리
- temperatureAfter 15 h the reaction mixture was cooled to ambient temperature
- extractionextracted with EtOAc (50 mL) three times
- dry with materialdried over Na2SO4
- filtrationfiltered
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-8449263808a54a5f9fea5e7a6e7676fa
- 출처 데이터셋
- uspto-grants-2014_03
- 특허 번호
- US08680275B2
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