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Dimethylformamide → 4-[3-[4-[Bis(4-methoxyphenyl)methyl]-1-piperidinyl]propoxy]benzoic acid ethyl ester fumarate hydrate

HRID 1193682
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HRID 1193682 반응식
CN(C)[CH:3]=[O:4].[CH3:6][O:7][C:8]1[CH:13]=[CH:12][C:11]([CH:14]([C:21]2[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][CH:22]=2)[CH:15]2[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)=[CH:10][CH:9]=1.[CH2:29]([O:31][C:32](=[O:44])[C:33]1[CH:38]=[CH:37][C:36]([O:39][CH2:40][CH2:41][CH2:42]Cl)=[CH:35][CH:34]=1)[CH3:30]>C(O)CCC>[OH2:4].[C:3]([OH:4])(=[O:7])/[CH:34]=[CH:33]/[C:32]([OH:44])=[O:31].[CH2:29]([O:31][C:32](=[O:44])[C:33]1[CH:38]=[CH:37][C:36]([O:39][CH2:40][CH2:41][CH2:42][N:18]2[CH2:19][CH2:20][CH:15]([CH:14]([C:21]3[CH:22]=[CH:23][C:24]([O:27][CH3:28])=[CH:25][CH:26]=3)[C:11]3[CH:10]=[CH:9][C:8]([O:7][CH3:6])=[CH:13][CH:12]=3)[CH2:16][CH2:17]2)=[CH:35][CH:34]=1)[CH3:30]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 144071674-[Bis(4-methoxyphenyl)methyl]piperidineHCID 18348522Ethyl 4-(3-chloropropoxy)benzoate

생성물 1

HCID 703733334-[3-[4-[Bis(4-methoxyphenyl)methyl]-1-piperidinyl]propoxy]benzoic acid ethyl ester fumarate hydrate

시약·촉매·용매 1

HCID 2631-Butanol용매

실험 절차

Following the procedure of Example 22, but substituting dimethylformamide at 73° C. for butanol, 4-[bis(4-methoxyphenyl)methyl]piperidine and 4-(3-chloropropoxy)benzoic acid ethyl ester were reacted to give the free base of the title compound which was reacted with fumaric acid, to give the white fumarate salt (recrystallizing from methanoldiethyl ether) in 27% yield, m.p. 147.5°-148.5° C.

후처리

  1. customat 73° C.
  2. customwere reacted

출처 및 근거

ORD 기록
ord-16a41b2c2b374449a63b131dcf11d5bb
출처 데이터셋
uspto-grants-1989_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04810713

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