Allyl bromide → HCID 21270717, 화합물

HRID 1193916노트

반응식

HRID 1193916 반응식
[CH2:1]([O:3][C:4]1[N:5]([C:15]2[CH:20]=[C:19]([OH:21])[C:18]([Br:22])=[CH:17][C:16]=2[F:23])[C:6](=[O:14])[CH:7]=[C:8]([C:10]([F:13])([F:12])[F:11])[N:9]=1)[CH3:2].[CH2:24](Br)[CH:25]=[CH2:26].[H-].[Na+]>CN(C)C=O>[CH2:1]([O:3][C:4]1[N:5]([C:15]2[CH:20]=[C:19]([O:21][CH2:26][CH:25]=[CH2:24])[C:18]([Br:22])=[CH:17][C:16]=2[F:23])[C:6](=[O:14])[CH:7]=[C:8]([C:10]([F:13])([F:11])[F:12])[N:9]=1)[CH3:2]

참가 물질

5

반응물 3

HCID 7841Allyl bromideHCID 24758Sodium hydrideHCID 212707472-ethoxy-1-(4-bromo-2-fluoro-5-hydroxyphenyl)-4-trifluoromethyl-6(1H)-pyrimidinone

생성물 1

HCID 21270717HCID 21270717, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

using 2-ethoxy-1-(4-bromo-2-fluoro-5-hydroxyphenyl)-4-trifluoromethyl-6(1H)-pyrimidinone and allyl bromide with sodium hydride in dimethylformamide there is obtained 2-ethoxy-1-[4-bromo-2-fluoro-5-(2-propenyloxy)-phenyl]-4-trifluoromethyl-6(1H)-pyrimidinone, m.p. 68°-70° C.;

출처 및 근거

ORD 기록
ord-6785f2092f3147acb9dec7abd3e03e60
출처 데이터셋
uspto-grants-1989_03
특허 번호
US04812164

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