Dimethylamine → N,N-dimethyl-5,6,7,8-tetrahydro-8-quinolinamine

HRID 1194702노트

반응식

HRID 1194702 반응식
Cl.Cl[CH:3]1[C:12]2[N:11]=[CH:10][CH:9]=[CH:8][C:7]=2[CH2:6][CH2:5][CH2:4]1.[CH3:13][NH:14][CH3:15].[Cl-].[Na+].[OH-].[Na+]>>[CH3:13][N:14]([CH3:15])[CH:3]1[C:12]2[N:11]=[CH:10][CH:9]=[CH:8][C:7]=2[CH2:6][CH2:5][CH2:4]1

참가 물질

5

반응물 4

HCID 674DimethylamineHCID 5234Sodium ChlorideHCID 14798Sodium HydroxideHCID 137121818-Chloro-5,6,7,8-tetrahydroquinoline hydrochloride

생성물 1

HCID 20073468N,N-dimethyl-5,6,7,8-tetrahydro-8-quinolinamine

실험 절차

4.08 g of 8-chloro-5,6,7,8-tetrahydroquinoline hydrochloride of Example 1 were mixed with stirring for 75 minutes in 20 ml of a 40% aqueous solution of dimethylamine and the mixture was heated for 1 hour at 65° C.±2° C., then allowed to cool to ambient temperature. The reaction medium was saturated with sodium chloride and 0.3 ml of 2N sodium hydroxide were added. After extracting with ether, the extracts were washed with water, dried, and the solvent was eliminated under reduced pressure to obtain 3.35 g of N,N-dimethyl-5,6,7,8-tetrahydro-8-quinolinamine which was used as is for the following step.

후처리

  1. temperaturethe mixture was heated for 1 hour at 65° C.±2° C.
  2. additionwere added
  3. extractionAfter extracting with ether
  4. washthe extracts were washed with water
  5. customdried

출처 및 근거

ORD 기록
ord-d048a1ff3b904ca3855c193a4104da26
출처 데이터셋
uspto-grants-1989_03
특허 번호
US04816465

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