Water → 1-(3,4-Dichlorobenzyl)-5-methylamino-1,2,3-triazole-4-carboxamide

HRID 1194719노트

반응식

HRID 1194719 반응식
[NH2:1][C:2]1[N:6]([CH2:7][C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[C:10]([Cl:15])[CH:9]=2)[N:5]=[N:4][C:3]=1[C:16]([NH2:18])=[O:17].CI.[C:21](=O)([O-])[O-].[K+].[K+].O>CN(C)C=O>[Cl:15][C:10]1[CH:9]=[C:8]([CH:13]=[CH:12][C:11]=1[Cl:14])[CH2:7][N:6]1[C:2]([NH:1][CH3:21])=[C:3]([C:16]([NH2:18])=[O:17])[N:4]=[N:5]1

참가 물질

6

반응물 4

HCID 962WaterHCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 140330335-Amino-1-(3,4-dichlorobenzyl)-1,2,3-triazole-4-carboxamide

생성물 1

HCID 230362371-(3,4-Dichlorobenzyl)-5-methylamino-1,2,3-triazole-4-carboxamide

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A mixture of 5-amino-1-(3,4-dichlorobenzyl)-1,2,3-triazole-4-carboxamide (2.86 g, 10.0 mmol), methyl iodide (1.42 g, 10.0 mmol), and potassium carbonate (1.38 g, 10 0 mmol) in N,N-dimethylformamide (20 ml) is stirred 48 hours at ambient temperature, poured into water (150 ml), and filtered. Chromatography provides 1-(3,4-dichloro- benzyl)-5-methylamino-1,2,3-triazole-4-carboxamide.

후처리

  1. filtrationfiltered

출처 및 근거

ORD 기록
ord-1e33b985dcb34611bb53d07b7c5c88fa
출처 데이터셋
uspto-grants-1989_03
특허 번호
US04816469

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