Sodium hydride → HCID 13013062, 화합물
반응식
[Cl-].[CH3:2][S+](C)(C)=O.[H-].[Na+].[H][H].[OH:11][C:12]1[CH:19]=[C:18]([CH3:20])[CH:17]=[CH:16][C:13]=1[CH:14]=[O:15]>O1CCCC1.O>[OH:15][CH:14]1[C:13]2[CH:16]=[CH:17][C:18]([CH3:20])=[CH:19][C:12]=2[O:11][CH2:2]1참가 물질
7
실험 절차
To a solution of trimethylsulfoxonium chloride (12.9 g) in tetrahydrofuran (200 ml) was added sodium hydride (2.4 g of 100%). This solution was heated at reflux until hydrogen evolution had ceased. 13.6 g of 2-hydroxy-4-methylbenzaldehyde dissolved in tetrahydrofuran (100 ml) was then added. The reaction mixture was refluxed until the reaction was complete (3 hours). It was then poured into water (600 ml), extracted with ether, the ether dried over sodium sulphate and evaporated to give 3-hydroxy-6-methyl-2,3-dihydrobenzofuran.
후처리
- temperatureThis solution was heated
- additionwas then added
- temperatureThe reaction mixture was refluxed until the reaction
- custom(3 hours)
- extractionextracted with ether
- dry with materialthe ether dried over sodium sulphate
- customevaporated
출처 및 근거
- ORD 기록
- ord-16e05b46acfe44c8b47b3c671b1a0282
- 출처 데이터셋
- uspto-grants-1989_03
- 특허 번호
- US04816473
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