Bromocycloheptane → ethyl (2Z)-2-cycloheptyloxyimino-3-oxobutanoate

반응식

[OH:1]/[N:2]=[C:3](/[C:9](=[O:11])[CH3:10])\[C:4]([O:6][CH2:7][CH3:8])=[O:5].[CH:12]1(Br)[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1>>[CH:12]1([O:1]/[N:2]=[C:3](/[C:9](=[O:11])[CH3:10])\[C:4]([O:6][CH2:7][CH3:8])=[O:5])[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1

참가 물질

반응물 2

HCID 16992Bromocycloheptane

HCID 178472876HCID 178472876, 화합물

생성물 1

HCID 14864956ethyl (2Z)-2-cycloheptyloxyimino-3-oxobutanoate수율 80%

실험 절차

Ethyl (Z)-2-(hydroxyimino)-3-oxobutyrate (5.Og) was treated with cycloheptyl bromide as described in Example 13a to give the title compound as a colourless liquid (6.36 g, 80%). (Found: M+ +H, 256.1547, C13H21NO4 requires M+H 256.1550), νmax (film) 2940, 1750, 1690 cm-1 ; δH (CDCl3): 1.31 (3H, t) 1.4-2.0 (12H, m), 2.35 (3H, s) 4.32 (3H, q+m).

출처 및 근거

ORD 기록: ord-1069e163489e4cd8ae85464d03751a8d
출처 데이터셋: uspto-grants-1989_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04816452

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