Water → (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[2-(diethylamino)-2-oxoethoxy]iminoacetic acid

HRID 1195069노트

반응식

HRID 1195069 반응식
[NH2:1][C:2]1[S:3][CH:4]=[C:5](/[C:7](=[N:13]/[O:14][CH2:15][C:16](=[O:22])[N:17]([CH2:20][CH3:21])[CH2:18][CH3:19])/[C:8]([O:10]CC)=[O:9])[N:6]=1.O.[OH-].[Na+]>CO>[NH2:1][C:2]1[S:3][CH:4]=[C:5](/[C:7](=[N:13]/[O:14][CH2:15][C:16](=[O:22])[N:17]([CH2:20][CH3:21])[CH2:18][CH3:19])/[C:8]([OH:10])=[O:9])[N:6]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 21269044HCID 21269044, 화합물

생성물 1

HCID 21269034(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[2-(diethylamino)-2-oxoethoxy]iminoacetic acid수율 402.7%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

68.1 g of ethyl 2-(2-amino-4-thiazolyl)-2-[(Z)-[(diethylcarbamoyl)methoxy]imino]-acetate are dissolved in 2.8 l of methanol and 240 ml of water and the solution is treated with 230 ml of 1N aqueous sodium hydroxide solution. The methanol is removed under reduced pressure after 48 hours and the aqueous solution is washed with ethyl acetate. After the addition of 230 ml of 1N aqueous hydrochloric acid, the crystallized acid is filtered off and dried. There are obtained 250.8 g of 2-(2-amino-4-thiazolyl)-2-[(Z)-[(diethylcarbamoyl)methoxy]imino]-acetic acid of melting point 180° C.

후처리

  1. customThe methanol is removed under reduced pressure after 48 hours
  2. washthe aqueous solution is washed with ethyl acetate
  3. additionAfter the addition of 230 ml of 1N aqueous hydrochloric acid
  4. filtrationthe crystallized acid is filtered off
  5. customdried

출처 및 근거

ORD 기록
ord-5730ed26a10b48a099a3cbc4a33b42f2
출처 데이터셋
uspto-grants-1989_03
특허 번호
US04816582

반응 노트

불러오는 중…