Hydrochloric Acid → 5-(Chloromethyl)-6-propyl-1,3-benzodioxole

HRID 1195281노트

반응식

HRID 1195281 반응식
CCCCOCCOCCO[CH2:12][C:13]1[CH:14]=[C:15]2[O:24][CH2:23][O:22][C:16]2=[CH:17][C:18]=1[CH2:19][CH2:20][CH3:21].[ClH:25].O>C1C=CC=CC=1>[CH2:19]([C:18]1[C:13]([CH2:12][Cl:25])=[CH:14][C:15]2[O:24][CH2:23][O:22][C:16]=2[CH:17]=1)[CH2:20][CH3:21]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 5794Piperonyl Butoxide

생성물 1

HCID 747395-(Chloromethyl)-6-propyl-1,3-benzodioxole

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

15 g of piperonyl butoxide and 300 ml of concentrated hydrochloric acid were dissolved in 100 ml of benzene and the solution was heated under reflux for 3 h. The reaction mixture was cooled to room temperature and water was added thereto. After extraction with ethyl acetate, the extract was washed with water, dried over magnesium sulfate and concentrated under reduced pressure to obtain 12 g of 6-propyl-5-chloromethyl-1,3-benzodioxole in the form of a faint brown oil.

후처리

  1. temperaturethe solution was heated
  2. temperatureunder reflux for 3 h
  3. extractionAfter extraction with ethyl acetate
  4. washthe extract was washed with water
  5. dry with materialdried over magnesium sulfate
  6. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-1278d1fec602435a80145e076215f150
출처 데이터셋
uspto-grants-1992_05
특허 번호
US05110956

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