Acetone → 3-Buten-2-one, 4-(2,3-dihydro-1H-inden-5-yl)-

HRID 1195455노트

반응식

HRID 1195455 반응식
[OH-].[Na+].[CH2:3]1[C:11]2[C:6](=[CH:7][C:8]([CH:12]=O)=[CH:9][CH:10]=2)[CH2:5][CH2:4]1.[CH3:14][C:15]([CH3:17])=[O:16]>O>[CH2:3]1[C:11]2[C:6](=[CH:7][C:8]([CH:12]=[CH:14][C:15](=[O:16])[CH3:17])=[CH:9][CH:10]=2)[CH2:5][CH2:4]1

참가 물질

5

반응물 3

HCID 180AcetoneHCID 14798Sodium HydroxideHCID 1216245-Indanecarboxaldehyde

생성물 1

HCID 40739273-Buten-2-one, 4-(2,3-dihydro-1H-inden-5-yl)-수율 81%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

An aqueous solution of 10% sodium hydroxide (50-70 ml) was added dropwise over a period of 5 minutes to a suspension of indane-5-carboxaldehyde (18.50 g; 127 mmole) in acetone (50 ml) and water (50 ml). The mixture was stirred at a temperature of 65° C. for a period of 11/2 hours and then extracted with dichloromethane (200 ml). The organic extract was washed several times with water, dried over anhydrous sodium sulphate, and the solvent was removed under reduced pressure using a rotary evaporator to give 1-(5-indanyl)but-1-en-3-one (19.25 g; 81%) as a viscous oil.

후처리

  1. extractionextracted with dichloromethane (200 ml)
  2. extractionThe organic extract
  3. washwas washed several times with water
  4. dry with materialdried over anhydrous sodium sulphate
  5. customthe solvent was removed under reduced pressure
  6. customa rotary evaporator

출처 및 근거

ORD 기록
ord-bb8f46a3df0542a6981a9802cbb25294
출처 데이터셋
uspto-grants-1992_05
특허 번호
US05110989

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