Sodium borohydride → 3-Hydroxymethyl-8-(2-(trans)-hydroxy-2,3-dihydro-1-indenyloxy)-2-methyl-imidazo[1,2-a]pyridine

HRID 1195726노트

반응식

HRID 1195726 반응식
[CH:1]([C:3]1[N:7]2[CH:8]=[CH:9][CH:10]=[C:11]([O:12][C@@H:13]3[C:21]4[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=4)[CH2:15][C@H:14]3[OH:22])[C:6]2=[N:5][C:4]=1[CH3:23])=[O:2].[BH4-].[Na+]>CO>[OH:2][CH2:1][C:3]1[N:7]2[CH:8]=[CH:9][CH:10]=[C:11]([O:12][C@@H:13]3[C:21]4[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=4)[CH2:15][C@H:14]3[OH:22])[C:6]2=[N:5][C:4]=1[CH3:23]

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 228438253-Formyl-8-(2-(trans)-hydroxy-2,3-dihydro-1-indenyloxy)-2-methyl-imidazo[1,2-a]pyridine

생성물 1

HCID 228438393-Hydroxymethyl-8-(2-(trans)-hydroxy-2,3-dihydro-1-indenyloxy)-2-methyl-imidazo[1,2-a]pyridine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

1 g of 3-formyl-8-(2-(trans)-hydroxy-2,3-dihydro-1-indenyloxy)-2-methyl-imidazo[1,2-a]pyridine is dissolved in 150 ml methanol, and excess sodium boro hydride is added in small portions at room temperature. After reduction has been completed, 150 ml icewater is added. The volatile components are evaporated in the rotary evaporator in vacuo. Subsequently extraction is carried out 3×with 40 ml ethyl acetate each time. The combined extracts are stripped off in vacuo of solvents, and the crystalline residue is recrystallized from methanol. The title compound of 192°-193° C. is obtained.

후처리

  1. addition150 ml icewater is added
  2. customThe volatile components are evaporated in the rotary evaporator in vacuo
  3. extractionSubsequently extraction
  4. customthe crystalline residue is recrystallized from methanol

출처 및 근거

ORD 기록
ord-08b224fb8b06463da23e30973a23365f
출처 데이터셋
uspto-grants-1992_05
특허 번호
US05112834

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