Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 5-(3,4-Dimethoxy-6-chlorophenyl)-2,4-pentadienoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 2-Chloro-4,5-dimethoxybenzaldehyde | HCID 279351 | — |
| 반응물 | Ethyl trans-crotonate | HCID 429065 | — |
| 반응물 | Potassium tert-butoxide | HCID 23665647 | — |
| 용매 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 생성물 | 5-(3,4-Dimethoxy-6-chlorophenyl)-2,4-pentadienoic acid | HCID 54056704 | — |
반응 단계
To a solution containing 10.0 g 3,4 dimethoxy-6-chlorobenzaldehyde and 8 ml of ethyl crotonate in 60 ml of N-methylpyrrolidone 6.0 g of potassium tert.-butoxide was added while stirring. The solution was stirred for 0.5 h more at 20° C. and poured then to a mixture of ice and hydrochloric acid. The solution was extracted with ether. The ether solution was washed with water and extracted with 2.5 N NaOH-solution. The aqueous phase was acidified with hydrochloric acid and the semisolid product was separated. Yield 10.8 g (81%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05112861 |
| 출처 데이터셋 | uspto-grants-1992_05 |
| ORD ID | ord-f06a397f135a47fdbe4b17ae82197583 |
| 출처 메모 | uspto-grants-1992_05 |