Hydrochloric Acid → HCID 67916022, 화합물

HRID 1196249노트

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HRID 1196249 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2([C:23]3[CH:28]=[CH:27][CH:26]=[C:25]([Cl:29])[CH:24]=3)[CH:16]3[CH:12]([CH2:13][N:14](C(OC=C)=O)[CH2:15]3)[C:11](=[O:22])[CH2:10][CH2:9]2)[CH:5]=[CH:6][CH:7]=1.Cl>O1CCOCC1.C(OC(C)C)(C)C>[ClH:1].[Cl:29][C:25]1[CH:24]=[C:23]([C:8]2([C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=3)[CH:16]3[CH:12]([CH2:13][NH:14][CH2:15]3)[C:11](=[O:22])[CH2:10][CH2:9]2)[CH:28]=[CH:27][CH:26]=1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 67915885(3aRS,7aRS)-7,7-bis(3-chlorophenyl)-2-vinyloxycarbonylperhydro-4-isoindolone

생성물 1

HCID 67916022HCID 67916022, 화합물수율 144.6%

시약·촉매·용매 2

HCID 7914Diisopropyl Ether용매HCID 312751,4-Dioxane용매

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온도
60 °C

실험 절차

(3aRS,7aRS)-7,7-Bis(3-chlorophenyl)-2-vinyloxycarbonylperhydro-4-isoindolone (1.5 g) is treated with a 6N solution (7.4 cc) of hydrochloric acid in dioxane for 2 hours at 25° C. The solution is concentrated to dryness under reduced pressure (2.7 kPa) and the residue is heated for 1 hour in solution in ethanol at 60° C. and then stirred for 6 hours at 25° C. The solution is concentrated to dryness under reduced pressure (2.7 kPa) and the meringue-like product obtained solidified in isopropyl ether. The precipitate is drained and washed with isopropyl ether, then dried to give 7,7-bis(3-chlorophenyl)perhydro-4-isoindolone hydrochloride (1 g).

후처리

  1. concentrationThe solution is concentrated to dryness under reduced pressure (2.7 kPa)
  2. concentrationThe solution is concentrated to dryness under reduced pressure (2.7 kPa)
  3. customthe meringue-like product obtained
  4. washwashed with isopropyl ether
  5. customdried

출처 및 근거

ORD 기록
ord-1a38d43c30e5465eb2f1aa29c17cf4e7
출처 데이터셋
uspto-grants-1992_05
특허 번호
US05112988

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