Benzylamine → HCID 12435486, 화합물

반응식

[CH2:1]([O:3][CH:4]([O:8][CH2:9][CH3:10])[C:5](Cl)=[O:6])[CH3:2].[CH2:11]([NH2:18])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>>[CH2:11]([NH:18][C:5](=[O:6])[CH:4]([O:8][CH2:9][CH3:10])[O:3][CH2:1][CH3:2])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

참가 물질

반응물 2

HCID 7504Benzylamine

HCID 19898726Diethoxyacetyl chloride

생성물 1

HCID 12435486HCID 12435486, 화합물

실험 절차

Ethyl diethoxyacetate (Ex. Fluka) (25 g) was added to sodium hydroxide (5.68 g) in ethanol (60 ml) and water (30 ml). After heating under reflux for 5 hours the solvents were removed at reduced pressure and the residue dried in vacuo to give sodium diethoxyacetate (23.2 g). The salt was then converted to diethoxyacetyl chloride and reacted with benzylamine to give N-benzyl diethoxyacetamide which was cyclised with conc. sulphuric acid according to Fukumi and Hideshi, Heterocycles, 9, 1197 (1978) to give 3-hydroxyisoquinoline.

출처 및 근거

ORD 기록: ord-1010de09e3ab4a09a58e340b0c33b324
출처 데이터셋: uspto-grants-1992_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05114940

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