Phosphate → 2-Monocaprin

HRID 1196810

반응식

HRID 1196810 반응식
CCCCCCCCCC([O:12][CH2:13][CH:14]([O:28][C:29]([CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH3:39])=[O:30])[CH2:15][O:16]C(CCCCCCCCC)=O)=O.P([O-])([O-])([O-])=O>C(O)CCC>[C:29]([O:28][CH:14]([CH2:13][OH:12])[CH2:15][OH:16])(=[O:30])[CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH3:39]

참가 물질

4

반응물 2

HCID 1061PhosphateHCID 69310Tricaprin

생성물 1

HCID 1379102-Monocaprin

시약·촉매·용매 1

HCID 2631-Butanol용매

반응 조건

온도
37 °C

실험 절차

Tridecanoin (45.0 mmole, 25.0 g) is dissolved in petroleum ether, b.p. 35° C.-60° C., (600 ml) and n-butanol (110 ml). This solution is mixed with 0.05 M phosphate buffer (110 ml) containing lipolase (Novo) 100L (9.0 g) and stirred at 37° C. for 3 hours. After separation of phases, the organic solution is evaporated at reduced pressure and temperature (below 30° C.) to a volume of about 100 ml. This solution is diluted with hexane (500 ml) and cooled to -78° C. using a dry ice-isopropanol bath. The precipitate is filtered below 0° C. and dried. Yield of 2-decanolyl glycerol is 7.2 g (65%).

후처리

  1. customAfter separation of phases
  2. customthe organic solution is evaporated at reduced pressure and temperature (below 30° C.) to a volume of about 100 ml
  3. additionThis solution is diluted with hexane (500 ml)
  4. temperaturecooled to -78° C.
  5. filtrationThe precipitate is filtered below 0° C.
  6. customdried

출처 및 근거

ORD 기록
ord-19dd00140d7d49ab8be5e8e217c356b7
출처 데이터셋
uspto-grants-1992_05
특허 번호
US05116745

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