Methyl iodide → 1-(2,4-Difluorophenyl)-2-(pyridin-3-yl)propan-1-one

HRID 1196939노트

반응식

HRID 1196939 반응식
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:17])[CH2:10][C:11]1[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=1.I[CH3:19]>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:17])[CH:10]([C:11]1[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=1)[CH3:19]

참가 물질

3

반응물 2

HCID 6328Methyl iodideHCID 189565241-(2,4-Difluorophenyl)-2-(3-pyridinyl)-ethanone

생성물 1

HCID 189565411-(2,4-Difluorophenyl)-2-(pyridin-3-yl)propan-1-one수율 73.6%

실험 절차

Methylation of the product of part (i) (5.0 g) with iodomethane (7.60 g) according to the method of Example 11(ii) gave the title compound as an oil (3.90 g) which was used directly in the next stage.

출처 및 근거

ORD 기록
ord-e3fe0713b35d4230a8b3914976606637
출처 데이터셋
uspto-grants-1992_05
특허 번호
US05116844

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