Hydrochloric Acid → HCID 178462135, 화합물

HRID 1197072노트

반응식

HRID 1197072 반응식
[N:1]1(C(OCC2C=CC=CC=2)=O)[C:5](=[O:6])[CH2:4][CH2:3][C@H:2]1[C:7]([NH:9][C@H:10]([C:12]([NH:14][C@H:15]([C:26]([OH:28])=[O:27])[CH2:16][CH2:17][CH2:18][NH:19][C:20](=[NH:25])[NH:21][N+]([O-])=O)=[O:13])[CH3:11])=[O:8].CO.Cl>[Pd].O>[NH:1]1[C:5](=[O:6])[CH2:4][CH2:3][C@H:2]1[C:7]([NH:9][C@H:10]([C:12]([NH:14][C@H:15]([C:26]([OH:28])=[O:27])[CH2:16][CH2:17][CH2:18][NH:19][C:20](=[NH:21])[NH2:25])=[O:13])[CH3:11])=[O:8]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 178462136HCID 178462136, 화합물

생성물 1

HCID 178462135HCID 178462135, 화합물수율 50.8%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 962Water용매

실험 절차

After 1.75 g (2.6 mmols) of Z-PyroGlu-Ala-Arg(NO2)-CHA was suspended in a solvent mixture of 112.5 ml of MeOH, 27.7 ml of H2O and 9.8 ml of 1N-HCl, 1 g of palladium black was added to the suspension followed by catalytic reduction at 30° C. for 6 hours. After the reaction, the catalyst was filtered off and the solvent was removed by distillation under reduced pressure. The residue was purified through TOYOPEARL HW40F column using MeOH as a developing solvent to give 0.471 g (34.4%) of H-PyroGlu-Ala-Arg-CHA.HCl.

후처리

  1. additionwas added to the suspension
  2. customAfter the reaction
  3. filtrationthe catalyst was filtered off
  4. customthe solvent was removed by distillation under reduced pressure
  5. customThe residue was purified through TOYOPEARL HW40F column

출처 및 근거

ORD 기록
ord-aeaa3c673fd643ca9ee65199d01496ef
출처 데이터셋
uspto-grants-1992_05
특허 번호
US05116941

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