Acetic Anhydride → 2,6-dimethyl-4H-3,1-benzoxazin-4-one

HRID 1197117노트

반응식

HRID 1197117 반응식
[CH3:1][C:2]1[CH:10]=[C:6]([C:7]([OH:9])=[O:8])[C:5]([NH2:11])=[CH:4][CH:3]=1.[C:12](OC(=O)C)(=O)[CH3:13]>>[CH3:12][C:13]1[O:8][C:7](=[O:9])[C:6]2[CH:10]=[C:2]([CH3:1])[CH:3]=[CH:4][C:5]=2[N:11]=1

참가 물질

3

반응물 2

HCID 7918Acetic AnhydrideHCID 762552-Amino-5-methylbenzoic acid

생성물 1

HCID 27965282,6-dimethyl-4H-3,1-benzoxazin-4-one

실험 절차

45.5 g (0.3 mol) of 5-Methylanthranilic acid are refluxed together with 130 g of acetic anhydride for 3 hours. After the solvent has been evaporated in vacuo, the residue is dissolved in 200 ml of dichloromethane, and the solution is filtered through silica gel. The concentrated filtrate is induced to crystallise with isopropyl ether.

후처리

  1. customAfter the solvent has been evaporated in vacuo
  2. dissolutionthe residue is dissolved in 200 ml of dichloromethane
  3. filtrationthe solution is filtered through silica gel
  4. customto crystallise with isopropyl ether

출처 및 근거

ORD 기록
ord-870075bdc07e436cbec7a3fd48b81d16
출처 데이터셋
uspto-grants-1992_05
특허 번호
US05116971

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