Hydrochloric Acid → HCID 15020029, 화합물

HRID 1197237노트

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HRID 1197237 반응식
Cl[C:2]1[CH:7]=[C:6]([Cl:8])[C:5]([S:9]([CH3:12])(=[O:11])=[O:10])=[CH:4][C:3]=1[N+:13]([O-:15])=[O:14].[CH3:16][O:17][CH:18](O)[CH3:19].[OH-:21].[K+].Cl>O>[CH3:16][O:17][CH2:18][CH2:19][O:21][C:2]1[CH:7]=[C:6]([Cl:8])[C:5]([S:9]([CH3:12])(=[O:11])=[O:10])=[CH:4][C:3]=1[N+:13]([O-:15])=[O:14]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 30156371-Methoxyethanol2회HCID 21876260HCID 21876260, 화합물

생성물 1

HCID 15020029HCID 15020029, 화합물

시약·촉매·용매 1

HCID 962Water용매

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온도
90 °C

실험 절차

To a mixture consisting of 50 g of 2,4-dichloro-5-methanesulfonylnitrobenzene and 150 ml of methoxyethanol was added dropwise a methoxyethanol solution of potassium hydroxide (potassium hydroxide 14.6 g/methoxyethanol 150 ml) while keeping the temperature at -5° C. or below. The reaction was carried out at -2° C. for 30 minutes and the reaction mixture was neutralized by adding 4 ml of concentrated hydrochloric acid. The neutralized mixture was heated to 90° C, whereby a uniform solution was formed. After the solution was cooled to 70° C., 220 ml of warm water was added dropwise thereto. The resulting precipitated crystal was recovered by filtration and dried to obtain 2-methoxyethoxy-4-chloro-5-methanesulfonylnitrobenzene. Yield: 50 g (87%).

후처리

  1. customat -5° C. or below
  2. customwhereby a uniform solution was formed
  3. temperatureAfter the solution was cooled to 70° C.
  4. customThe resulting precipitated crystal
  5. filtrationwas recovered by filtration
  6. customdried

출처 및 근거

ORD 기록
ord-8a0054b3566d47d785699ef7922dd82e
출처 데이터셋
uspto-grants-1992_05
특허 번호
US05117064

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