Sodium Hydroxide → 5-Benzofuranacetic acid

HRID 1197620노트

반응식

HRID 1197620 반응식
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][C:11]([O:13]C)=[O:12])=[CH:9][C:4]=2[CH:3]=[CH:2]1.[OH-].[Na+]>CO.O>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][C:11]([OH:13])=[O:12])=[CH:9][C:4]=2[CH:3]=[CH:2]1

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 19748760Methyl 2-(benzofuran-5-YL)acetate

생성물 1

HCID 234388925-Benzofuranacetic acid수율 99.1%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

Methyl benzofuran-5-ylacetate (1.2 gm, 6.3 mmol) was dissolved in methanol (10 mL) and 2N sodium hydroxide (6.5 mL) was added under nitrogen and the mixture was stirred at rt for 3 hr. It was then diluted with water and extracted with ether. The aqueous layer was acidified with 2N hydrochloric acid and again extracted twice with ethyl acetate. The organic layers were washed with brine, combined, dried over sodium sulfate and evaporated to give 1.1 gm of title compound suitable for the next step.

후처리

  1. extractionextracted with ether
  2. extractionagain extracted twice with ethyl acetate
  3. washThe organic layers were washed with brine
  4. dry with materialdried over sodium sulfate
  5. customevaporated

출처 및 근거

ORD 기록
ord-7af57701591b44779936a1ccb6deb275
출처 데이터셋
uspto-grants-1994_01
특허 번호
US05276139

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