Acetic Acid → 2-Chloro-4-ethyl-5-fluoropyrimidine
반응식
[Cl:1][C:2]1[N:7]=[C:6](Cl)[C:5]([F:9])=[CH:4][N:3]=1.[C:10](O)(=O)[CH3:11]>Cl>[Cl:1][C:2]1[N:7]=[C:6]([CH2:10][CH3:11])[C:5]([F:9])=[CH:4][N:3]=1참가 물질
4
반응 조건
- 온도
- 100 °C
실험 절차
The product of part (i) (3.2 g) was dissolved in acetic acid (25 ml) and diluted with 5N HCl (10 ml). After heating the mixture at 100° C. for 16 hours the mixture was cooled and partitioned between water (30 ml) and dichloromethane (45 ml). The dichloromethane layer was separated, dried and concentrated under reduced pressure to give an oil. The title compound was isolated by chromatography on silica gel using dichloromethane as the eluent. The product was characterised by 1H-NMR and mass spectrometry (yield=350 mg).
후처리
- temperaturewas cooled
- custompartitioned between water (30 ml) and dichloromethane (45 ml)
- customThe dichloromethane layer was separated
- customdried
- concentrationconcentrated under reduced pressure
- customto give an oil
출처 및 근거
- ORD 기록
- ord-e2ac9bc9ddae4580ae6584d4f520c031
- 출처 데이터셋
- uspto-grants-1994_01
- 특허 번호
- US05278175
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