4-Chlorostyrene → 1-[Dimethyl(1-methylethoxy)silyl]-4-ethenylbenzene

HRID 1197900

반응식

HRID 1197900 반응식
[CH:1]([O:4][Si:5]([CH3:8])([CH3:7])Cl)([CH3:3])[CH3:2].[CH:9]([C:11]1[CH:16]=[CH:15][C:14]([Mg]Cl)=[CH:13][CH:12]=1)=[CH2:10].C(C1C=CC(Cl)=CC=1)=C.[Mg]>C1COCC1>[CH:9]([C:11]1[CH:16]=[CH:15][C:14]([Si:5]([CH3:8])([CH3:7])[O:4][CH:1]([CH3:3])[CH3:2])=[CH:13][CH:12]=1)=[CH2:10]

참가 물질

6

반응물 4

HCID 140854-ChlorostyreneHCID 5462224MagnesiumHCID 13033739Chloro(dimethyl)[(propan-2-yl)oxy]silaneHCID 178436504HCID 178436504, 화합물

생성물 1

HCID 189616131-[Dimethyl(1-methylethoxy)silyl]-4-ethenylbenzene수율 45%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

반응 조건

온도
10 °C

실험 절차

A solution of isopropoxydimethylchlorosilane (15.2 g, 100 mmole) in dry THF (50 mL) was added dropwise over a 1 hour period to a solution of (4-vinylphenyl)magnesium chloride, prepared from 4-vinylphenyl chloride (13.85 g, 100 mmole) and magnesium (3.0 g, 125 mmole) in dry 100 mL THF. The temperature was maintained at 10° C. during the addition. The reaction mixture was stirred at room temperature for over 18 hours. The desired product distilling at 45°-49° C./0.2 mm was obtained in 45% yield.

후처리

  1. distillationThe desired product distilling at 45°-49° C./0.2 mm
  2. customwas obtained in 45% yield

출처 및 근거

ORD 기록
ord-03f27159cd4f48c8bc89eff936c386cd
출처 데이터셋
uspto-grants-1994_01
특허 번호
US05278244

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