Trifluoroacetic acid → HCID 70048063, 화합물

HRID 1197929노트

반응식

HRID 1197929 반응식
[CH:1]1([CH2:7][C@H:8]([NH:18]C(=O)OC(C)(C)C)[C@@H:9]([OH:17])[CH2:10][N:11]2[CH2:15][CH2:14][CH2:13][C:12]2=[O:16])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.FC(F)(F)C(O)=O.C(=O)([O-])[O-].[Na+].[Na+].[OH-].[Na+]>C(Cl)Cl>[NH2:18][C@@H:8]([CH2:7][CH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1)[C@@H:9]([OH:17])[CH2:10][N:11]1[CH2:15][CH2:14][CH2:13][C:12]1=[O:16]

참가 물질

6

반응물 4

HCID 6422Trifluoroacetic acidHCID 10340Sodium CarbonateHCID 14798Sodium HydroxideHCID 86747488HCID 86747488, 화합물

생성물 1

HCID 70048063HCID 70048063, 화합물수율 84.4%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

0.41 g (1.16 mmol) of t-butyl [(1S,2S)-1-(cyclohexylmethyl)-2-hydroxy-3-(2-oxo-1-pyrrolidinyl)propyl]carbamate was dissolved in 5 ml of methylene chloride, treated at 0° with 1.5 ml of 90% trifluoroacetic acid and subsequently stirred at room temperature for 5 hours. Thereafter, the reaction mixture was slowly added dropwise to 2N sodium carbonate solution, subsequently treated with 3N sodium hydroxide solution and finally extracted with methylene chloride. The methylene chloride extracts were dried over potassium carbonate and evaporated under reduced pressure, whereby there were obtained 249 mg of 1-[(2S,3S)-3-amino4-cyclohexyl-2-hydroxybutyl]-2-pyrrolidinone as an oil, MS: 255 (M+H)+.

후처리

  1. extractionfinally extracted with methylene chloride
  2. dry with materialThe methylene chloride extracts were dried over potassium carbonate
  3. customevaporated under reduced pressure

출처 및 근거

ORD 기록
ord-146e9cf388f548f89ce69fa31b7941ea
출처 데이터셋
uspto-grants-1994_01
특허 번호
US05278148

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