Phenethylamine → Methyl 2-(phenethylamino)acetate
반응식
[C:1]1([CH2:7][CH2:8][NH2:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Br[CH2:11][C:12]([O:14][CH3:15])=[O:13]>C1(C)C=CC=CC=1>[C:1]1([CH2:7][CH2:8][NH:9][CH2:11][C:12]([O:14][CH3:15])=[O:13])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1참가 물질
4
실험 절차
To a stirred solution of 2-phenylethylamine (9.68 g, 40 mmol) in toluene (50 mL) was added methyl bromoacetate (6.12 g, 20 mmol) dropwise at room temperature and was left stirring for 18 hours. The reaction mixture was filtered before removing the solvent in vacuo and the residue was purified by chromatography over silica gel to yield 4.8 g (61%) of the title compound as an oil. NMR (250 MHz, CDCl3) δ (1H, s), 2.92 (4H, m), 3.43 (2H, s), 3.71 (2H, s), 7.27 (5H, m).
후처리
- waitwas left
- filtrationThe reaction mixture was filtered
- custombefore removing the solvent in vacuo
- customthe residue was purified by chromatography over silica gel
출처 및 근거
- ORD 기록
- ord-58b2afecc5d94c0eaaacd595f2a7de3b
- 출처 데이터셋
- uspto-grants-1994_01
- 특허 번호
- US05278316
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