Potassium Carbonate → HCID 178418677, 화합물

HRID 1198322

반응식

HRID 1198322 반응식
[F:1][C:2]1[C:7]([F:8])=[C:6]([O:9][CH2:10][CH2:11][CH2:12][CH3:13])[CH:5]=[CH:4][C:3]=1[OH:14].[CH2:15]([C@H:20]1[CH2:25][CH2:24][C@H:23]([CH2:26]Br)[CH2:22][CH2:21]1)[CH2:16][CH2:17][CH2:18][CH3:19].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH2:10]([O:9][C:6]1[CH:5]=[CH:4][C:3]([O:14][CH2:26][C@H:23]2[CH2:24][CH2:25][C@H:20]([CH2:15][CH2:16][CH2:17][CH2:18][CH3:19])[CH2:21][CH2:22]2)=[C:2]([F:1])[C:7]=1[F:8])[CH2:11][CH2:12][CH3:13]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 191034334-Butoxy-2,3-difluorophenolHCID 178444389HCID 178444389, 화합물

생성물 1

HCID 178418677HCID 178418677, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

0.1 mol of 2,3-difluoro-4-butoxyphenol, 0.11 mol of trans-4-pentylcyclohexylmethyl bromide and 0.11 mol of potassium carbonate are heated at 100° in 100 ml of dimethylformamide (DMF) for 16 hours. After cooling, the inorganic salts are filtered off with suction, the filtrate is concentrated and water is added. Extraction with methylene chloride gives 1-butoxy-2,3-difluoro-4-(trans-4-pentylcyclohexylmethoxy)benzene.

후처리

  1. temperatureAfter cooling
  2. filtrationthe inorganic salts are filtered off with suction
  3. concentrationthe filtrate is concentrated
  4. additionwater is added
  5. extractionExtraction with methylene chloride

출처 및 근거

ORD 기록
ord-1bae8b3220744c4abf0f5bfe7aab8377
출처 데이터셋
uspto-grants-1994_01
특허 번호
US05279764

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