Toluene → (4-Octyloxy-2,3-difluorophenyl)-4-propylbenzylideneamine

HRID 1198333

반응식

HRID 1198333 반응식
[CH2:1]([O:9][C:10]1[CH:16]=[CH:15][C:13]([NH2:14])=[C:12]([F:17])[C:11]=1[F:18])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[CH2:19]([C:22]1[CH:29]=[CH:28][C:25]([CH:26]=O)=[CH:24][CH:23]=1)[CH2:20][CH3:21].C1(C)C=CC(S(O)(=O)=O)=CC=1.C1(C)C=CC=CC=1>O>[CH2:1]([O:9][C:10]1[CH:16]=[CH:15][C:13]([N:14]=[CH:26][C:25]2[CH:28]=[CH:29][C:22]([CH2:19][CH2:20][CH3:21])=[CH:23][CH:24]=2)=[C:12]([F:17])[C:11]=1[F:18])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

참가 물질

6

반응물 4

HCID 1140TolueneHCID 6101p-Toluenesulfonic acidHCID 1200474-PropylbenzaldehydeHCID 19103699HCID 19103699, 화합물

생성물 1

HCID 53700525(4-Octyloxy-2,3-difluorophenyl)-4-propylbenzylideneamine

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 0.1 mol of 4-octyloxy-2,3-difluoroaniline (prepared from the corresponding amide by a Hoffmann rearrangement), 0.1 mol of 0.1 mol of 4-propylbenzaldehyde, 0.01 mol of p-toluenesulfonic acid and 200 ml of toluene is heated at the boiling point for 2 hours using a water separator. Customary working up gives (4 -octyloxy-2,3-difluorophenyl)-4-propylbenzylideneamine.

후처리

  1. temperatureis heated at the boiling point for 2 hours

출처 및 근거

ORD 기록
ord-57591a8a019f4316908f5443038ffd6d
출처 데이터셋
uspto-grants-1994_01
특허 번호
US05279764

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