참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | Diisobutylaluminum hydride | HCID 14487 | — |
| 반응물 | trans-3-[2-(7-Chloroquinolin-2-yl)ethenyl]benzyl alcohol | HCID 10827738 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 3-[2(E)-(2-Pyridyl)ethenyl]benzyl alcohol | HCID 70341855 | — |
반응 단계
The methyl benzoate (Example 37b part ii) (2.25 g, 9.4 mmol) was dissolved in dry toluene (60 ml) and cooled to -70° C. under nitrogen. 1M DIBAL in dichloromethane (18.8 ml, 18.8 mmol) was added over 15 minutes and the reaction mixture allowed to warm up to -30° C. for 30 minutes. The reaction was quenched by careful addition of methanol (8 ml), then water, and after filtration through Celite the organic phase was evaporated in vacuo.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05281593 |
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| 출처 데이터셋 | uspto-grants-1994_01 |
|---|
| ORD ID | ord-f12ccb71f6ac4577a2b2f68c674ebacb |
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| 출처 메모 | uspto-grants-1994_01 |
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