Hydroxyamine hydrochloride → HCID 85126173, 화합물

HRID 1198609노트

반응식

HRID 1198609 반응식
Cl.[NH2:2][OH:3].[C:4]([CH:7]1[CH2:11][N:10]([CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:9](=[O:19])[CH2:8]1)(=O)[CH3:5]>N1C=CC=CC=1>[CH2:12]([N:10]1[CH2:11][CH:7]([C:4](=[N:2][OH:3])[CH3:5])[CH2:8][C:9]1=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

참가 물질

4

반응물 2

HCID 443297Hydroxyamine hydrochlorideHCID 100820724-Acetyl-1-benzylpyrrolidin-2-one

생성물 1

HCID 85126173HCID 85126173, 화합물수율 104.2%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

Hydroxylamine hydrochloride (5.58 g, 0.076 mole) was added to a solution of 4-acetyl-1-benzyl-2-pyrrolidinone (15.0 g, 0.069 mole) in pyridine (250 mL) and the reaction mixture was heated at 40° with stirring under nitrogen for 18 hours. The solvent was removed under reduced pressure at 65° and the residue was dissolved in chloroform (900 mL), washed with water (500 mL), 0.5M HCl (3×500 mL), and dried (MgSO4). The solvent was removed under reduced pressure to give 1-benzyl-4-(1-hydroxyiminoethyl)-2-oxo-pyrrolidine (16.7 g, quant) as a brown solid.

후처리

  1. temperaturethe reaction mixture was heated at 40°
  2. customThe solvent was removed under reduced pressure at 65°
  3. dissolutionthe residue was dissolved in chloroform (900 mL)
  4. washwashed with water (500 mL), 0.5M HCl (3×500 mL)
  5. dry with materialdried (MgSO4)
  6. customThe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-c8d4adb04f3d45a7bc88b685d7233f59
출처 데이터셋
uspto-grants-1994_01
특허 번호
US05281612

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